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TB-500: Works systemically throughout the body to promote cell migration, reduce inflammation, and enhance tissue repair

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Studies were rejected if they were not in English, were duplicates, lacked full-text access, or consisted just of abstracts or comments without empirical data

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was funded by the PRIME JP17gm5910013 and the LEAP JP17gm0010004 from the Japan Agency for Medical Research and Development, and JSPS KAKENHI 17K08264

Common side effects include nausea, vomiting, diarrhea, and constipation, which typically improve as the dose is gradually increased